Top 10 Best Supplements for Men Over 40

As men reach their 40s, their bodies undergo several significant changes that impact overall health and well-being.

This period often brings about unique health challenges, including declining testosterone levels, loss of muscle mass, and an increased risk of cardiovascular disease and prostate issues.

Addressing these changes through targeted nutrition and supplementation is crucial for maintaining optimal health and vitality.

That’s why I wrote this article to explore the specific health problems faced by men over 40 and highlight the top 10 supplements that can help manage these challenges effectively, ensuring a robust and healthy lifestyle.

Specific Health Problems and Nutrition Needs for Men Over 40

As men age, they face unique health challenges such as declining testosterone, muscle loss, and increased risk of cardiovascular and prostate issues.

Addressing these through targeted nutrition and supplementation is crucial for maintaining health and well-being.

Testosterone Decline

Testosterone levels drop with age, leading to reduced muscle mass, libido, and energy. Zinc and vitamin D are vital for maintaining hormonal balance.

Muscle Mass and Strength

Aging leads to sarcopenia, impacting physical performance. Protein, BCAAs, and creatine supplements help maintain muscle mass and strength.

Cardiovascular Health

The risk of heart disease increases with age. Omega-3 fatty acids, CoQ10, and magnesium support heart health and reduce cardiovascular risks.

Prostate Health

Prostate issues become more common with age. Selenium, lycopene, and saw palmetto support prostate health and may lower risk.

Bone Health

Men over 40 are at risk of osteoporosis. Calcium, vitamin D, and vitamin K2 are crucial for bone density and preventing fractures.

Metabolic Health

Metabolic syndrome becomes more prevalent with age. Chromium, alpha-lipoic acid, and fiber help regulate blood sugar, support weight management, and improve lipid profiles.

Best Supplements for Men 40+

I selected these specific supplements for men over 40 because they offer substantial benefits across multiple aspects of health, enhancing overall quality of life.

By addressing common age-related issues such as hormonal balance, muscle maintenance, cardiovascular health, and prostate support, these supplements can significantly improve physical performance, vitality, and well-being.

1.) Protein Powder

Protein powder supplements are undoubtedly one of the best supplements for men over 40, especially when combined with a healthy diet and regular exercise.

As men age, they tend to lose muscle mass, leading to decreased strength, mobility, and overall health.

Supplementing with protein powder, like whey or plant-based protein supplements, can help combat this by providing the body with the necessary amino acids to build and maintain muscle.

Garden of Life Protein and Greens is an excellent example of a high-quality plant-based protein powder that can benefit men over 40.

Garden of Life Raw Protein & Greens is made from a blend of organic pea protein, sprouted brown rice protein, and other organic greens and vegetables to provide a complete amino acid profile and a range of nutrients for optimal health.

In addition to supporting muscle growth and repair, Garden of Life Raw Protein & Greens also contains digestive enzymes and probiotics to promote healthy digestion and nutrient absorption.

This can be especially beneficial for men over 40 who may experience digestive issues or have difficulty absorbing nutrients from their food.

Another advantage of Garden of Life Raw Protein & Greens is that it is free from artificial flavors, sweeteners, and preservatives, making it a clean and natural source of protein.

Lastly, it is vegan, gluten-free, and dairy-free, making it suitable for a wide range of dietary preferences and restrictions.

Overall, supplementing with protein powder, such as Garden of Life Raw Protein & Greens, can be an easy and effective way for men over 40 to maintain and build muscle mass, support overall health, and enhance their physical performance.

Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.

2.) Creatine Monohydrate

Creatine monohydrate is one of the most well-researched supplements, offering significant benefits for muscle mass, body composition, and brain health, making it particularly beneficial for men over 40.

As men age, maintaining a healthy body composition becomes more challenging due to hormonal changes and muscle loss.

Creatine helps counteract this by increasing the body’s ability to produce energy rapidly, enhancing strength and endurance during high-intensity workouts.

This leads to greater muscle hypertrophy, improved muscle definition, and fat loss.

Additionally, creatine facilitates the production of adenosine triphosphate (ATP), essential for energy in muscle cells.

This allows for more intense workouts and promotes muscle repair and growth, which is especially valuable for men over 40 experiencing age-related muscle loss, as it helps preserve muscle mass and improve physical performance.

Additionally, creatine supports brain health by enhancing cellular energy production in the brain, which can improve cognitive function, memory, and mental clarity.

Research suggests creatine supplementation enhances brain function, particularly in tasks requiring short-term memory and quick thinking.

Incorporating creatine monohydrate into their supplement regimen helps men over 40 experience significant improvements in muscle mass, body composition, and cognitive health, contributing to a more active, healthy, and fulfilling life.

There are many protein, amino acid and pre-workout supplements that contain creatine monohydrate, but you could also buy a standalone creatine monohydrate supplement like Optimum Nutrition Creatine Monohydrate:

Last update on 2025-04-16 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.

3.) Colostrum

Colostrum supplements, derived from the nutrient-rich first milk produced by mammals after giving birth, offer significant health benefits for men over 40.

Packed with essential growth factors, antibodies, and bioactive compounds, colostrum supports immune function, gut health, and muscle recovery.

As men age, their immune systems can weaken, increasing susceptibility to illnesses.

Colostrum’s immunoglobulins bolster immune response, providing better protection against common illnesses.

Additionally, colostrum promotes gut health by repairing the gut lining and reducing inflammation, which is crucial for men who may experience digestive issues. These properties also make colostrum an excellent supplement for assisting men who want to lose weight fast.

The insulin-like growth factors (IGFs) in colostrum support muscle repair and growth, enhance protein synthesis, accelerate recovery times, and speed up the rate of improving body composition.

Colostrum also promotes collagen production and cellular regeneration, offering anti-aging benefits that improve skin elasticity and reduce wrinkles.

Two excellent brands I’ve used that provided noticeable benefits are Force Factor Primal Origins Colostrum and ARMRA Colostrum.

Incorporating these colostrum supplements into your routine can enhance immune function, gut health, muscle recovery, and skin health, making them valuable additions for maintaining vitality and overall well-being.

Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.

4.) Collagen

Collagen supplements are vital for men over 40, providing numerous benefits including support for joint health, skin elasticity, and overall physical wellness.

Collagen is the most abundant protein in the body, crucial for maintaining the integrity of skin, joints, and connective tissues.

As men age, natural collagen production declines, leading to joint discomfort, reduced skin elasticity, and other aging-related issues.

Bovine collagen supplements (made from cows) help counteract this decline by promoting joint health and reducing symptoms of arthritis.

They provide the necessary building blocks to repair and maintain cartilage, which can alleviate joint pain and improve mobility.

Collagen supplements can be particularly beneficial for men who lead active lifestyles or engage in regular physical exercise to prevent and manage joint-related issues.

In addition to joint support, collagen supplements play a significant role in enhancing skin health.

They help improve skin elasticity and hydration, reducing the appearance of wrinkles and fine lines, which leads to a more youthful and vibrant appearance, which is often a concern for men over 40.

Furthermore, collagen supports muscle recovery and growth. It contains amino acids that aid in muscle repair and regeneration, which is crucial for maintaining muscle mass and strength as men age.

Regular collagen supplementation can improve muscle recovery times and support overall physical performance.

There are various forms of collagen supplements available, with BioCell Collagen and hydrolyzed collagen being two popular types.

BioCell is a unique combination of collagen and hyaluronic acid, known for its bioavailability and effectiveness in promoting joint and skin health.

Hydrolyzed collagen, also known as collagen peptides, is processed to break down the protein into smaller, more easily absorbed particles, making it highly effective for various health benefits.

While Vital Proteins is the most well-known collagen company, I have found Purely Inspired Collagen Peptides to be a great alternative for hydrolyzed collagen.

It offers similar quality at a more affordable price, making it a practical choice for those looking to incorporate collagen into their daily regimen without breaking the bank.

When comparing collagen vs colostrum, both offer unique benefits.

Collagen primarily supports joint, skin, and muscle health, while colostrum enhances immune function, gut health, and muscle recovery.

Including both in your supplement regimen can provide comprehensive health benefits, addressing the unique needs of men over 40.

Last update on 2025-04-16 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.

5.) Synbiotics (Probiotics + Prebiotics)

The gut plays a crucial role in maintaining an individual’s overall health and well-being.

It is home to trillions of microorganisms, collectively referred to as the gut microbiome, which play a critical role in maintaining the proper functioning of the body’s systems.

When the balance of bacteria in the gut is disrupted, it can lead to a wide range of health issues, including digestive problems, weakened immune function, and even mental health problems.

One way to support gut health and maintain a balanced gut microbiome is through synbiotics, a combination of probiotics and prebiotics.

Probiotics are live microorganisms that, when consumed in sufficient quantities, provide a range of health benefits.

They are commonly found in foods like yogurt, kefir, and sauerkraut, but they can also be taken from soil-based organisms like in Kimberly Snyders’s vegan probiotic supplement.

Prebiotics, on the other hand, are non-digestible fibers that serve as food for the beneficial bacteria in the gut.

Synbiotics work by promoting the growth of beneficial bacteria and helping to maintain a healthy balance of microorganisms in the gut, which can lead to improved digestion, increased nutrient absorption, and better immune function.

In fact, research has shown that synbiotic supplementation can even have a positive impact on mental health, as the gut and brain are closely connected through the gut-brain axis.

For men over 40, synbiotic supplementation can be particularly beneficial.

As we age, the composition of the gut microbiome changes, with a decrease in the number of beneficial bacteria and an increase in harmful bacteria.

This can lead to various health issues, including digestive problems, weakened immune function, and an increased risk of chronic diseases.

Fortunately, synbiotic supplementation can help support gut health and maintain a balanced gut microbiome in men over 40.

One excellent synbiotic supplement for men is Ora Organic Trust Your Gut.

Ora Organic Trust Your Gut contains a unique combination of prebiotics and probiotics to support gut health and maintain a healthy microbiome.

Last update on 2025-04-16 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.

6.) Fish Oil

Fish oil supplements, rich in omega-3 fatty acids, offer a variety of benefits, making them one of the best supplements for men over 40.

These fatty acids support heart health by reducing inflammation, improving cholesterol levels, and lowering blood pressure, while also promoting brain function and reducing the risk of cognitive decline.

Moreover, omega-3s can help slow the aging process, keep the body youthful, and reduce the incidence of dementia or Alzheimer’s disease.

In addition to these benefits, fish oil is an excellent supplement for muscle gain and weight loss, particularly for men over 40 who want to preserve lean muscle mass.

Research has shown that fish oil-derived n-3 PUFA therapy can slow the normal decline in muscle mass and function in older adults, making it a therapeutic approach for preventing sarcopenia and maintaining physical independence.

In my opinion, the best fish oil supplement you should try is Nordic Naturals Ultimate Omega:

Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.

7.) Vitamin D

Vitamin D, also known as the “sunshine vitamin,” is an essential nutrient that supports almost all bodily functions, making it one of the best supplements for men over 40.

Vitamin D is critical for bone health, immune function, and mood regulation.

Unfortunately, with age, the body’s ability to synthesize vitamin D from sunlight decreases, increasing the risk of nutrient deficiencies.

Research indicates that vitamin D plays an important role in bone metabolism and has anti-inflammatory and immune-modulating properties.

Furthermore, research suggests that vitamin D deficiency is associated with several health issues, including an increased risk of osteoporosis, cancer, diabetes, and hypertension.

Sadly, vitamin D deficiency is all too common, especially for older men.

Inadequate sun exposure and lack of vitamin D-rich foods in the diet can contribute to this issue.

While exercising outdoors can help with vitamin D absorption, it may not always be enough.

Supplementing with vitamin D can help men over 40 maintain strong bones, support immune health, and reduce the risk of depression and other mood disorders.

Furthermore, research has found that vitamin D supplementation may even reduce the risk of certain cancers, such as colorectal, breast, and prostate.

Just remember, when choosing a vitamin D supplement, it’s crucial to opt for one that also contains vitamin K2 to promote blood flow through the veins and avoid any potential issues with blood clotting.

Sports Research Vitamin D3 + K2 is an excellent vitamin D supplement with numerous benefits, making it one of the best available.

First, it contains a high dose of 5000iu of plant-based vitamin D3.

Secondly, it also contains 100mcg of vitamin K2 as MK-7, which supports the proper distribution of calcium in the body, reducing the risk of calcium buildup in the arteries and supporting cardiovascular health.

Thirdly, Sports Research Vitamin D3 + K2 is non-GMO verified and vegan-certified, making it a safe and healthy choice for vegans and vegetarians.

Finally, Sports Research Vitamin D3 + K2 is free from harmful additives, such as gluten, soy, and dairy, making it an excellent choice for those with dietary restrictions or allergies.

Overall, Sports Research Vitamin D3 + K2 is an outstanding vitamin D supplement that offers a high dose of plant-based vitamin D3 combined with vitamin K2 for optimal absorption and distribution.

Last update on 2025-04-16 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.

8.) Turmeric

Turmeric is one of my favorite supplements, and I certainly believe it is one of the best supplements for men over 40.

This incredible spice contains a powerful compound called curcumin, which can help reduce inflammation and pain associated with arthritis and other prevalent joint issues while also supporting heart health and cognitive function.

According to the research, curcumin exhibits anti-inflammatory, antioxidant, anti-carcinogenic, anti-mutagenic, anticoagulant, anti-diabetic, antibacterial, anti-fungal, antiprotozoal, antiviral, antifibrotic, antivenom, anti-ulcer, hypotensive, and hypocholesterolemic activities.

One of the most notable health benefits of turmeric is its ability to reduce inflammation throughout the body, which is a source of many health challenges.

Turmeric is an excellent anti-inflammatory herb, and it can help ease conditions such as bursitis, arthritis, and back pain.

Turmeric’s anti-inflammatory action includes lowering histamine levels and increasing the production of natural cortisone by adrenal glands.

For men over 40 who are dealing with joint pain, according to a study published in Holistic Nursing Practice, curcumin extracts are as effective as ibuprofen for treating pain in knee osteoarthritis (OA).

Furthermore, turmeric is known for its ability to burn fat and increase basal metabolic rate, so men over 40 can use turmeric for weight loss goals.

Lastly, turmeric supplements can also help improve sexual health in men over 40.

A study published in Andrologia compared a turmeric supplement with the erectile dysfunction medicine tadalafil (Cialis) and found that a novel curcumin derivative or its combination with tadalafil showed significant superiority and a more prolonged duration of action.

Turmeric curcumin is commonly combined with black pepper and ginger, which helps increase its absorption rate.

Overall, turmeric supplements are an excellent addition to the diet for men over 40.

Last update on 2025-04-16 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.

9.) Maca Root

Maca root, a Peruvian herb, is a natural supplement used for centuries to support men’s health.

This adaptogen is one of the best supplements for men over 40 because it can help manage stress, increase energy levels, and boost libido.

Adaptogens are known for their ability to help the body cope with stress, and maca root is no exception.

As men age, their stress levels can increase, leading to fatigue and other health issues.

Maca root can help manage stress and increase energy levels, allowing men to maintain vitality as they age.

Furthermore, maca root has been traditionally used to address common sexual health problems and improve stamina and hormonal balance.

According to a study published in Andrologia, maca supplementation can have a significant effect on subjective perception of general and sexual well-being in adult patients with mild erectile dysfunction.

Although the research is not conclusive on whether or not maca root supplements can increase testosterone or affect other important male hormones, it is evident that maca root has beneficial effects for men over 40.

In addition, maca root is also rich in vitamins and minerals that support overall health, including vitamin C, copper, iron, and potassium.

It is also a good source of plant-based protein and fiber, making it a nutritious addition to a balanced diet.

Overall, maca root is a generally safe and natural supplement that can help men over 40 maintain their vitality and support their overall health and well-being.

Natgrown Organic Maca Root Powder Capsules is a top maca root supplement that offers a potent blend of black, red, and yellow Peruvian maca root extract, providing a well-rounded approach to maca root supplementation.

It is organic, vegan, easy to consume, and free from harmful additives, making it a convenient and healthy option for anyone looking to incorporate maca root into their daily routine.

Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.

10.) Calcium

As people age, their bones become more fragile and susceptible to fractures.

The National Osteoporosis Foundation states that men over 50 have an increased risk of fractures due to osteoporosis, with one in four men experiencing a fracture related to the disease.

Calcium is an essential mineral critical in maintaining bone health as it is the primary building block of bone tissue and helps keep bones strong and dense.

However, the body cannot produce calcium independently, so it must be obtained through diet or supplements for bone health.

According to The American Journal of Clinical Nutrition, low calcium intakes are associated with low bone mass, rapid bone loss, and increased fracture rates, and calcium supplementation in older men and women has been shown to modestly increase bone mineral density.

However, it is important to note that calcium supplementation should not be the only solution.

A balanced diet rich in calcium-containing foods such as dairy, leafy greens, and nuts, along with regular exercise, is crucial for maintaining healthy bones.

One excellent calcium supplement for men over 40 is Juveriente Bone Strength.

Juveriente Bone Strength combines calcium, phosphorus, vitamin C, vitamin D3, and vitamin K2 to promote healthy bone density and strength.

The addition of phosphorus and vitamin D3 aids in the absorption and utilization of calcium, while vitamin K2 helps to direct calcium to the bones where it is needed most.

In addition to maintaining healthy bones, calcium also plays a crucial role in muscle and nerve function.

Last update on 2025-04-16 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.