Best Nootropics for Energy & How to Use Nootropics for Energy
Reading Time: 8 minutes Nootropics are a class of substances that boost brain performance by altering the availability of neurotransmitters, enzymes, hormones, and oxygen to the brain, and stimulating brain nerve growth.
Due to their unique abilities, many people buy and use nootropics for energy and brain performance.
Although you may feel intimidated or scared to use nootropics, considering the definition I provided above, many nootropics are completely safe, and some are incredibly common (like caffeine).
Along with using nootropics for energy, people can also use nootropics to improve their focus, increase their motivation to do work, and enhance their creativity.
I will discuss more about this product below, but I believe the best nootropic supplement for energy is Cognitune NuClarity:
Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.
Let’s look at some of the best nootropics for energy and learn more about how you can use nootropics to improve your life!
Disclaimer: Proceed with Caution and Make Informed Choices
While nootropics promise increased cognitive performance, sharper focus, and enhanced energy, it’s crucial to approach these compounds with a measure of caution.
Not all nootropics have undergone rigorous scientific testing, and some could pose risks to health that are yet to be thoroughly understood.
For instance, substances like adrafinil and phenylpiracetam are frequently touted for their purported energy-boosting benefits, but research indicates many safety concerns.
However, adrafinil has been linked to elevated liver enzymes, thereby implying potential hepatotoxicity.
Similarly, the long-term effects of phenylpiracetam on the human body are not well-studied.
That said, when used responsibly, certain nootropics like L-theanine and caffeine have shown promise in boosting energy and cognitive functions.
If you decide to explore nootropics, follow these guidelines for a safer experience:
- Consult a Medical Professional: Before adding any new supplement to your routine, seek the advice of a healthcare provider, particularly if you have pre-existing medical conditions or are taking other medications.
- Start with Lower Doses: Begin with a lower dose than recommended and gradually scale up to monitor how your body reacts.
- Check for Interactions: Be aware of how the nootropic might interact with other medications or supplements you’re taking.
- Research: Prioritize nootropics that have undergone peer-reviewed studies and have demonstrated safety and efficacy over those with scant or anecdotal evidence.
- Quality Over Quantity: Choose high-quality nootropics from reputable manufacturers who provide Certificates of Analysis and adhere to Good Manufacturing Practices.
I urge you to make smart, informed decisions when it comes to nootropics. Your health and well-being are too important to leave to chance or unverified claims.
Best Energy-Boosting Nootropics
The best nootropics for energy go beyond just providing a quick boost—they enhance mental clarity, endurance, and resilience against fatigue without the crashes associated with stimulants.
Some work by stimulating neurotransmitters like dopamine and acetylcholine, while others support mitochondrial function and brain circulation to sustain long-term cognitive performance.
Whether you need increased focus for a demanding workday, better stamina for intense training, or just an overall lift in mental energy, these nootropics can help optimize your performance.
The best nootropics for energy provide a combination of mental clarity, endurance, and reduced fatigue without causing crashes.
Some work by stimulating neurotransmitters, while others support mitochondrial function and brain circulation.
Here are some of the best nootropics for energy:
Caffeine + L-Theanine
- How it Works: Combining caffeine with L-theanine creates one of the best nootropic stacks for energy and focus. Caffeine provides an immediate boost by blocking adenosine, while L-theanine counteracts jitters and enhances relaxation, leading to smoother, more sustained focus (Einöther & Giesbrecht, 2013).
- Best for: Quick mental and physical energy boost without overstimulation.
For most people, an upper limit of 400mg of caffeine per day is tolerable, but you should be mindful to stop your caffeine consumption 6-9 hours before heading to sleep.
A great nootropic with a simple formulation of caffeine and L-theanine is Cognitune NuBoost:
Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.
I also suggest Four Sigmatic Boost as it contains coffee along with L-Theanine and other adaptogens for energy:
Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.
Rhodiola Rosea
- How it Works: Rhodiola Rosea is one of the best nootropics for energy when dealing with stress and mental fatigue. As an adaptogen, it enhances endurance, reduces fatigue, and supports cognitive function, particularly in high-pressure situations (Shevtsov et al., 2003).
- Best for: Sustained mental stamina and resilience under stress.
Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.
Panax Ginseng
- How it Works: Panax ginseng is one of the best nootropics for energy due to its ability to enhance dopamine and acetylcholine levels. These neurotransmitters play a key role in mental sharpness and motivation, making it effective for reducing cognitive fatigue and improving sustained performance (Reay et al., 2005).
- Best for: Prolonged focus and cognitive endurance.
Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.
Acetyl-L-Carnitine (ALCAR)
- How it Works: Acetyl L-carnitine is one of the best nootropics for energy at the cellular level, supporting mitochondrial function and ATP production. This makes it particularly useful for reducing both mental and physical fatigue while enhancing cognitive function (Malaguarnera et al., 2007).
- Best for: Physical endurance and brain energy optimization.
In my opinion, Dr Martin’s Nutrition L-Carnitine is the best l-carnitine supplement due to price and quality:
Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.
Creatine
- How it Works: Creatine is widely known for its role in athletic performance, but it is also one of the best nootropics for energy and mental clarity. By increasing ATP production in brain cells, creatine enhances cognitive function, making it ideal for individuals with high mental workloads (McMorris et al., 2007).
- Best for: Mental endurance and sustained cognitive performance with high workloads.
Creatine monohydrate is the most effective form of creatine, and I believe Optimum Nutrition Creatine Monohydrate is the best creatine supplement:
Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.
Coenzyme Q10 (CoQ10) & PQQ
- How it Works: CoQ10 and PQQ are two of the best nootropics for energy at the mitochondrial level, enhancing cellular function and reducing fatigue. By improving mitochondrial efficiency, they help sustain brain energy and cognitive function (Hernández-Camacho et al., 2018).
- Best for: Brain endurance and long-term cellular energy support.
Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.
Modafinil (Prescription Nootropic)
For those of you looking for help managing narcolepsy, Modalert (also known as modafinil) is a common prescription medication.
- How it Works: Modafinil is one of the best prescription nootropics for energy, known for its ability to promote wakefulness and enhance mental performance. It works by modulating dopamine and orexin levels, making it particularly effective for individuals struggling with extreme fatigue or long work sessions (Minzenberg & Carter, 2008).
- Best for: Combatting extreme fatigue and maintaining prolonged cognitive function.
If you are looking for more information on drugs such as Modalert and others, Drugs Bank is a reliable source.
Cordyceps Mushroom
- How it Works: Cordyceps mushroom is one of the best nootropics for energy because it enhances oxygen utilization and ATP production. It has long been used in traditional medicine for its ability to improve stamina and reduce fatigue, making it beneficial for both mental and physical endurance (Chen et al., 2010).
- Best for: Natural energy enhancement and sustained stamina.
Four Sigmatic Boost contains caffeine from coffee along with cordyceps mushroom and L-Theanine for energy and focus:
Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.
Tyrosine
- How it Works: L-Tyrosine is one of the best nootropics for energy when dealing with mental stress and fatigue. As a precursor to dopamine and norepinephrine, it helps maintain focus, motivation, and cognitive function in demanding situations (Deijen et al., 1999).
- Best for: High-pressure environments requiring focus and mental agility.
In my opinion, NOW Foods L-Tyrosine is the best L-tyrosine supplement as it provides an adequate dosage and is relatively affordable. You can also find L-tyrosine in many energy drinks and pre workout supplements.
Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.
Nicotinamide Riboside (NR) & NMN
- How it Works: NR and NMN are some of the best nootropics for energy at the cellular level, as they support mitochondrial function by boosting NAD+ levels. This helps improve endurance, brain function, and overall energy metabolism (Fang et al., 2016).
- Best for: Long-term brain health and anti-fatigue support.
Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.
Ginkgo Biloba
- How it Works: Ginkgo biloba is one of the best nootropics for energy, particularly for enhancing blood circulation in the brain. This increased blood flow can support cognitive function, memory, and mental clarity (Mashayekh et al., 2011). It is commonly used to combat cognitive decline but also benefits healthy individuals looking to improve brain function.
- Best for: Improved blood flow, memory, and overall cognitive vitality.
Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.
Lion’s Mane Mushroom
- How it Works: Lion’s Mane Mushroom is among the best nootropics for energy and brain health due to its ability to promote nerve regeneration. It contains compounds that stimulate Nerve Growth Factor (NGF), which aids in cognitive function and neurological recovery (Lai et al., 2013). Lion’s Mane is often consumed in supplement form or as a tea and has gained popularity as a natural brain booster.
- Best for: Brain regeneration, cognitive support, and long-term mental energy.
There are a variety of supplements that contain Lion’s Mane Mushroom, but I suggest you try Four Sigmatic “Think,” which combines Lion’s Mane Mushroom with other adaptogens and nootropics:
Last update on 2025-04-15 / This article includes affiliate links/Images via Amazon Product Advertising API. I may earn commissions on purchases made through these links.
Should You Combine Multiple Nootropics for Energy?
For a more effective nootropic experience, you can combine some of the best nootropics for energy to improve their effects. Taking multiple nootropics at one time is known as “stacking,” and many nootropic users do this.
Stacking your nootropic options means stacking benefits.
If you are starting with nootropic stacking, you might have problems choosing what kind of compounds or herbs you are going to use. Some of the safest choices are already well-known combinations, like caffeine and L-Theanine.
If you want to try nootropic stacking, you should be very careful with what you choose to combine. Some compounds and herbs do not work well together, and some are even considered dangerous.
As I mentioned before, I believe the best nootropic supplement for energy is Cognitune NuClarity, which combines several nootropics into one supplement
Cognitune NuCLarity contains:
- Ginkgo Biloba
- L-Carnitine
- Bacopa Monnieri
- Alpha-GPC
- Phosphatidylserine
- Rhodiola Rosea
- Huperzine A
As you can see, I have already mentioned many of these nootropics as the best nootropics for energy, which is why this is an effective product. I have used Cognitune NuClarity myself, and I found it very useful.
Additionally, Cognitune NuClarity is:
- Caffeine Free
- All Natural
- Non-GMO
- Produced in an FDA Approved GMP Facility
Another example of a nootropic supplement that has stacked various nootropics is Mind Lab Pro.
Final Thoughts: The Best Nootropics for Energy
Incorporating the best nootropics for energy into your daily routine can significantly enhance mental clarity, focus, and endurance. However, it’s essential to choose high-quality nootropics from reputable sources to ensure safety and effectiveness.
Not all nootropic supplements are created equal, and factors like dosage, purity, and potential interactions with other supplements or medications should be carefully considered.
Additionally, while nootropics can provide a powerful cognitive boost, they work best when combined with a healthy lifestyle, including proper nutrition, hydration, sleep, and stress management.
Over-reliance on nootropics without addressing foundational health habits may lead to diminishing returns over time.
If you’re looking to optimize your mental and physical performance, selecting the right nootropics for energy can be a game-changer—but always do your research and consult with a healthcare professional when necessary.
For more information on nootropics, you can check out Nootropics Review Nerd.
